Description

4-(Trifluoromethoxy)Benzonitrile is a versatile aromatic nitrile building block distinguished by its trifluoromethoxy substituent. This compound is valued for its unique combination of lipophilicity, metabolic stability, and electronic properties, making it a critical intermediate in advanced chemical synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes due to its stable aromatic core and fluorine content.
• Polymer & Resin Modifiers: Incorporated into high-performance polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano group transformations for constructing complex molecular architectures.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction pathways and material properties.

Basic Information

Product Name	4-(Trifluoromethoxy)Benzonitrile
CAS No.	332-25-2
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	p-(Trifluoromethoxy)benzonitrile; 4-(Trifluoromethoxy)phenyl cyanide; 1-Cyano-4-(trifluoromethoxy)benzene; α,α,α-Trifluoro-p-anisonitrile; Benzonitrile, 4-(trifluoromethoxy)-; 4-Cyanophenyl trifluoromethyl ether
EINECS	206-371-5

Quality Control

Our 4-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	34 - 38 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.