Description

2-Chloro-5-(Trifluoromethyl)Benzonitrile is a versatile aromatic nitrile building block characterized by its chloro and trifluoromethyl substituents. This compound is highly valued in advanced chemical synthesis for its ability to introduce both halogen and fluorine-containing functional groups into target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in creating advanced polymers, ligands for catalysis, and other performance materials requiring specific electronic properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) for constructing complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new synthetic methodologies and compound libraries.

Basic Information

Item	Details
Product Name	2-Chloro-5-(Trifluoromethyl)Benzonitrile
CAS No.	328-87-0
Molecular Formula	C8H3ClF3N
Molecular Weight	205.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-tolunitrile; 2-Chloro-α,α,α-trifluoro-4-methylbenzonitrile; 4-Cyano-2-chlorobenzotrifluoride; 2-Chloro-5-(trifluoromethyl)benzenecarbonitrile; 2-Chloro-α,α,α-trifluoro-p-toluonitrile; 2-Chloro-5-(trifluoromethyl)phenyl cyanide; p-Cyano-2-chlorobenzotrifluoride; Benzonitrile, 2-chloro-5-(trifluoromethyl)-
EINECS	206-340-5

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.