Description

3-Methoxy-5-Nitrobenzotrifluoride is a versatile aromatic trifluoromethylated intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both electron-donating methoxy and electron-withdrawing nitro and trifluoromethyl groups, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Serves as a core building block for developing new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials, contributing to the molecular framework of liquid crystals and organic light-emitting diodes.
• Dye & Pigment Manufacturing: Intermediate for synthesizing specialized dyes and pigments, where the nitro and methoxy groups influence color and fastness properties.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer chains, enhancing material properties like chemical resistance, thermal stability, and dielectric characteristics.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling and nucleophilic aromatic substitution reactions.

Basic Information

Item	Detail
Product Name	3-Methoxy-5-Nitrobenzotrifluoride
CAS No.	328-79-0
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	5-Nitro-3-(trifluoromethyl)anisole; 1-Methoxy-3-nitro-5-(trifluoromethyl)benzene; 3-Methoxy-α,α,α-trifluoro-5-nitrotoluene; 3-Methoxy-5-nitrobenzylidene trifluoride; 3-Methoxy-5-nitro-α,α,α-trifluorotoluene; 5-Nitro-m-trifluoromethylanisole; 3-(Trifluoromethyl)-5-nitroanisole; 328-79-0 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 3-Methoxy-5-Nitrobenzotrifluoride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics is provided with every shipment to guarantee it meets your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.