Description

3,5-Bis(Trifluoromethyl)Nitrobenzene is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring two strong electron-withdrawing trifluoromethyl groups and a nitro substituent, makes it a critical intermediate for creating complex molecules with tailored electronic and physical properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where its fluorinated aromatic core contributes to improved pest selectivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in transition metal catalysis, enabling more efficient and selective chemical transformations.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors, liquid crystals, and other electronic materials due to its ability to modify electron affinity and molecular packing.
• Dye and Pigment Intermediate: Functions as a building block for creating novel fluorinated dyes and pigments with enhanced lightfastness and chemical resistance.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems important in material science and drug discovery.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Nitrobenzene
CAS No.	328-75-6
Molecular Formula	C8H3F6NO2
Molecular Weight	259.11 g/mol
Synonyms	1-Nitro-3,5-bis(trifluoromethyl)benzene; 3,5-Di(trifluoromethyl)nitrobenzene; Nitro-3,5-bis(trifluoromethyl)benzene; Benzene, 1-nitro-3,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-3,5-dimethyl-4-nitrobenzene; 3,5-Bis(trifluoromethyl)-1-nitrobenzene
EINECS	206-331-6

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Nitrobenzene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards through rigorous in-process and final release testing, including identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.