Description

1-Chloro-5-Fluoro-2,4-Dinitrobenzene is a versatile halogenated nitroaromatic compound that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This high-purity intermediate is essential for researchers and manufacturers requiring a reliable and consistent source for constructing heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug molecules, particularly those containing fluorinated and nitro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its reactive halogen and nitro groups.
• Dye and Pigment Manufacturing: Acts as a precursor for specialized azo dyes and other colorants requiring specific halogen and nitro functionalities.
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig aminations for creating biaryl structures.
• Nucleophilic Aromatic Substitution: The activated chlorine and fluorine atoms make it an excellent candidate for displacement reactions with various nucleophiles.

Basic Information

Product Name	1-Chloro-5-Fluoro-2,4-Dinitrobenzene
CAS No.	327-91-3
Molecular Formula	C6H2ClFN2O4
Molecular Weight	220.54 g/mol
Synonyms	2,4-Dinitro-1-chloro-5-fluorobenzene; 5-Fluoro-2,4-dinitrochlorobenzene; 1-Chloro-5-fluoro-2,4-dinitrobenzene; 2-Chloro-4,6-dinitrofluorobenzene; 4,6-Dinitro-2-chlorofluorobenzene; FDNB-Cl; 5-Fluoro-1-chloro-2,4-dinitrobenzene; Benzene, 1-chloro-5-fluoro-2,4-dinitro-
EINECS	206-333-6

Quality Control

Our 1-Chloro-5-Fluoro-2,4-Dinitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of our global clientele in fine chemical and pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and specific impurity limits are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.