Description

2-Fluoro-4-Bromonitrobenzene is a versatile halogenated nitroaromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring fluorine, bromine, and nitro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This high-purity intermediate is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and brominated aromatic cores.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and pesticides where the halogenated nitrobenzene scaffold provides specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex halogenated dyes and organic pigments.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Nucleophilic Aromatic Substitution: The fluorine atom is activated by the ortho-nitro group, making it reactive towards various nucleophiles for further functionalization.

Basic Information

Item	Detail
Product Name	2-Fluoro-4-Bromonitrobenzene
CAS No.	321-23-3
Molecular Formula	C6H3BrFNO2
Molecular Weight	219.99 g/mol
Synonyms	1-Bromo-2-fluoro-5-nitrobenzene; 4-Bromo-2-fluoronitrobenzene; 2-Fluoro-4-bromo-1-nitrobenzene; 5-Bromo-2-fluoronitrobenzene; 2-Fluoro-4-bromonitrobenzol; 4-Bromo-2-fluoronitrobenzen; (2-Fluoro-4-bromophenyl)nitro
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-4-Bromonitrobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, and we support compliance with cGMP and ISO 9001 standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.