Description

2-Bromo-4,5-difluoronitrobenzene is a versatile halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it a highly reactive intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorophenyl or aryl bromide motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine atom.
• Nucleophilic Aromatic Substitution: The electron-deficient nitro group activates the ring for substitution reactions with various nucleophiles.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of fluorine atoms on aromatic system reactivity and physical properties.

Basic Information

Product Name	2-Bromo-4,5-Difluoronitrobenzene
CAS No.	321-17-5
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-nitrobenzene; 2,3-Difluoro-4-nitro-1-bromobenzene; Benzene, 1-bromo-2,3-difluoro-4-nitro-; 2-Bromo-1,2-difluoro-4-nitrobenzene; 4-Nitro-2,3-difluorobromobenzene; 2,3-Difluoro-6-nitro-1-bromobenzene; 2-Bromo-4,5-difluoro-1-nitrobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5-difluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.