Description

2,5-Bis(Trifluoromethyl)Nitrobenzene is a high-value fluorinated aromatic building block characterized by its electron-deficient nitro and trifluoromethyl substituents. This compound is essential for advanced organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials where its unique electronic properties are leveraged. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring trifluoromethyl groups to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the nitro and CF3 groups contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and electronic materials for their unique dielectric and surface properties.
• Organic Electronics: Acts as a building block for electron-transport materials and n-type semiconductors in OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent for exploring novel nucleophilic aromatic substitution (SNAr) reactions and other transformations involving activated aryl halides.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Nitrobenzene
CAS No.	320-88-7
Molecular Formula	C8H3F6NO2
Molecular Weight	259.11 g/mol
Synonyms	1-Nitro-2,5-bis(trifluoromethyl)benzene; 2,5-Di(trifluoromethyl)nitrobenzene; 2,5-Bis(trifluoromethyl)-1-nitrobenzene; α,α,α,α',α',α'-Hexafluoro-2,5-dimethylnitrobenzene; Benzene, 2,5-bis(trifluoromethyl)-1-nitro-; 2,5-Bis(trifluoromethyl)nitrobenzene; 2,5-Bis(trifluoromethyl)nitrobenzol
EINECS	Contact for details

Quality Control

Our 2,5-Bis(Trifluoromethyl)Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.