Description

4-Nitro-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both a nitro and a trifluoromethyl group on a benzonitrile core. This unique structure makes it a critical building block for synthesizing advanced molecules in demanding research and industrial applications. It is primarily sought after by pharmaceutical, agrochemical, and advanced material scientists for the development of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic molecules where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the nitro and trifluoromethyl groups contribute to potent biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating specialized aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Dye & Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments, especially azo dyes, where it contributes to color fastness and specific hue properties.
• Cross-Coupling Reactions: The nitro and cyano groups make it a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D labs for exploring novel synthetic pathways and creating libraries of compounds for screening.

Basic Information

Product Name	4-Nitro-2-(Trifluoromethyl)Benzonitrile
CAS No.	320-47-8
Molecular Formula	C8H3F3N2O2
Molecular Weight	216.12 g/mol
Synonyms	2-(Trifluoromethyl)-4-nitrobenzonitrile; 4-Nitro-2-trifluoromethylbenzonitrile; 2-Cyano-5-nitrobenzotrifluoride; 5-Nitro-2-(trifluoromethyl)benzonitrile; 2-Trifluoromethyl-4-nitrobenzonitrile; α,α,α-Trifluoro-4-nitro-o-tolunitrile; Benzonitrile, 4-nitro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Nitro-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.