Description

4-Hydroxy-2-(Trifluoromethyl)Benzonitrile is a versatile aromatic nitrile derivative characterized by a hydroxyl group and a trifluoromethyl substituent. This compound is a critical high-purity building block for advanced synthesis, offering a unique combination of electronic and steric properties imparted by the fluorine atoms. It is primarily utilized by pharmaceutical, agrochemical, and material science research and development teams to create novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anticancer drugs.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of advanced electronic materials for displays and lighting, leveraging its polarizable structure and thermal stability.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for engineering plastics and high-performance polymers with specific optical or chemical resistance properties.
• Organic Synthesis & Catalysis: Employed as a ligand precursor or a specialized reagent in cross-coupling reactions and other catalytic processes.
• Dye & Pigment Intermediate: Utilized in the manufacture of specialized dyes and pigments where the cyano and hydroxyl groups facilitate chromophore development.

Basic Information

Product Name	4-Hydroxy-2-(Trifluoromethyl)Benzonitrile
CAS No.	320-42-3
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	2-Cyano-5-(trifluoromethyl)phenol; 2-Hydroxy-5-(trifluoromethyl)benzonitrile; 4-Hydroxy-α,α,α-trifluoro-o-tolunitrile; 5-(Trifluoromethyl)salicylonitrile; 2-Trifluoromethyl-4-hydroxybenzonitrile; 5-Cyano-2-(trifluoromethyl)phenol; 2-Hydroxy-α,α,α-trifluoro-p-tolunitrile
EINECS	206-277-8

Quality Control

Our 4-Hydroxy-2-(Trifluoromethyl)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.