Description

11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is a key phosphorylated derivative of a corticosteroid, offering enhanced solubility and stability for advanced pharmaceutical formulations. This compound is critical for researchers and manufacturers requiring a precise, high-purity intermediate for the synthesis of potent anti-inflammatory and immunosuppressive agents. It is primarily utilized by the pharmaceutical industry in the development of injectable and topical corticosteroid medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of high-potency corticosteroid drugs, such as prednisolone phosphate.
• Anti-inflammatory Drug Research: Used in R&D for developing new therapeutic agents targeting inflammation and autoimmune disorders.
• Injectable Formulations: Its phosphate ester group improves water solubility, making it suitable for parenteral (injectable) drug products.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Employed in studies investigating steroid hormone action, receptor binding, and metabolic pathways.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate)
CAS No.	302-25-0
Molecular Formula	C21H29O8P
Molecular Weight	440.42 g/mol
Synonyms	Prednisolone 21-Phosphate; Prednisolone Phosphate; 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate); NSC-100039; Prednisolone 21-(Dihydrogen Phosphate); Prednisolone 21-Phosphate Ester; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-phosphate
EINECS	206-119-3

Quality Control

Our 11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is manufactured under strict quality management systems. We offer material compliant with pharmaceutical-grade standards, with typical purity exceeding 98.0% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.