Description

(2S,4S)-4-Fluoro-2-Methylpyrrolidine Hydrochloride is a high-purity, chiral building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and metabolic diseases. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to incorporate a fluorinated pyrrolidine scaffold into their molecular designs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, especially in protease inhibitor and receptor modulator programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and stereochemistry on biological activity and metabolic stability.
• Process Chemistry & Scale-up: Serves as a starting material or advanced intermediate in the optimization and commercial-scale synthesis of target molecules.
• Agrochemical Research: Potential application as a building block for novel crop protection agents and pesticides.
• Ligand Synthesis: Can be utilized in the preparation of chiral ligands for asymmetric catalysis.
• Academic & Institutional R&D: Employed in universities and research institutes for exploratory synthetic chemistry and methodological studies.

Basic Information

Product Name	(2S,4S)-4-Fluoro-2-Methylpyrrolidine Hydrochloride
CAS No.	2828444-34-2
Molecular Formula	C5H11FN • HCl
Molecular Weight	139.60 (Free base) / 176.06 (HCl salt)
Synonyms	(2S,4S)-4-Fluoro-2-methylpyrrolidine HCl; (4S)-4-Fluoro-(2S)-2-methylpyrrolidine hydrochloride; 4-Fluoro-2-methylpyrrolidine hydrochloride, (2S,4S)-; 2-Methyl-4-fluoropyrrolidine hydrochloride, (2S,4S)-; Pyrrolidine, 4-fluoro-2-methyl-, hydrochloride, (2S,4S)-; (2S,4S)-2-Methyl-4-fluoropyrrolidine HCl; FC-1137 (Potential research code)
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Fluoro-2-Methylpyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing key parameters such as chiral purity, assay, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.