Description

(R)-3-(1-Aminoethyl)-4-Fluorobenzonitrile Hydrochloride CAS NO 2802461-28-3 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel drugs, especially those targeting neurological and oncological pathways where fluorinated aromatic systems are critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial-scale synthesis of novel, enantiomerically pure active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to construct complex molecules with high stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs, particularly for CNS and oncology targets.
• Preclinical Development: Serves as a critical material for producing batches of candidate drugs for pharmacological and toxicological evaluation.
• Process Chemistry: Utilized in the development and scale-up of efficient, cost-effective synthetic routes for potential commercial drug manufacturing.

Basic Information

Product Name	(R)-3-(1-Aminoethyl)-4-Fluorobenzonitrile Hydrochloride
CAS No.	2802461-28-3
Molecular Formula	C9H10FN2•HCl
Molecular Weight	200.65 (Free base) / 237.11 (HCl salt)
Synonyms	(R)-3-(1-Aminoethyl)-4-fluorobenzonitrile HCl; (R)-3-(1-Aminoethyl)-4-fluorobenzonitrile hydrochloride; (R)-α-Methyl-4-fluoro-m-cyanobenzylamine hydrochloride; (R)-1-(3-Cyano-4-fluorophenyl)ethylamine hydrochloride; (R)-3-(1-Aminoethyl)-4-fluorobenzonitrile monohydrochloride; (R)-4-Fluoro-3-(1-aminoethyl)benzonitrile hydrochloride; Benzonitrile, 3-[(1R)-1-aminoethyl]-4-fluoro-, hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(1-Aminoethyl)-4-Fluorobenzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric excess (ee) and standard pharmacopeial methods for purity and identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.