Description

Doxylamine Hydrogen Succinate is the succinate salt form of the first-generation ethanolamine antihistamine, doxylamine. This compound is valued for its high purity and consistent quality, making it a critical active pharmaceutical ingredient (API) for reliable formulation. It is primarily required by pharmaceutical manufacturers for the production of sedative and antiemetic medications, as well as by research institutions for pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in over-the-counter (OTC) sleep aid formulations.
• Antiemetic Preparations: Used in medications to prevent and treat nausea and vomiting.
• Veterinary Pharmaceuticals: Incorporated into sedative or anti-allergy formulations for animal health.
• Clinical Research: Serves as a reference standard or active compound in pharmacokinetic and pharmacodynamic studies.
• Formulation Development: Used in R&D for developing new solid dosage forms like tablets and capsules.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC and other assay methods.

Basic Information

Product Name	Doxylamine Hydrogen Succinate
CAS No.	2731375-61-2
Molecular Formula	C21H28N2O2 • C4H6O4
Molecular Weight	388.46 g/mol (for succinate salt)
Synonyms	Doxylamine Succinate; Doxylamine Hydrogen Succinate Salt; 2-[1-Phenyl-1-(2-pyridyl)ethoxy]-N,N-dimethylethanamine succinate; Doxylamine (as succinate); Histadoxylamine Succinate; Decapryn Succinate; UNII-8U87223A1F
EINECS	Contact for details

Quality Control

Our Doxylamine Hydrogen Succinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other pharmacopoeial tests is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.