Description

Benzonitrile, 2-Bromo-4-Chloro-6-(Cyclopropyloxy)-3-Fluoro- is a highly functionalized, multi-halogenated benzonitrile derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its complex structure, featuring bromo, chloro, fluoro, and cyclopropyloxy substituents, makes it a valuable scaffold for constructing molecules with precise steric and electronic properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its unique substitution pattern enables fine-tuning of biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective research programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogen and ether groups contribute to target specificity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals, leveraging its aromatic core and functional handles.
• Chemical Biology Probe Development: Utilized as a core structure for creating fluorescent tags or photoaffinity labels due to the modifiable nitrile and halogen groups.
• Organic Synthesis Scaffold: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, where the bromo and chloro groups act as excellent leaving groups.

Basic Information

Product Name	Benzonitrile, 2-Bromo-4-Chloro-6-(Cyclopropyloxy)-3-Fluoro-
CAS No.	2629317-94-6
Molecular Formula	C10H6BrClFNO
Molecular Weight	290.52 g/mol
Synonyms	2-Bromo-4-chloro-6-(cyclopropyloxy)-3-fluorobenzonitrile; 3-Fluoro-2-bromo-4-chloro-6-(cyclopropoxy)benzonitrile; 2-Bromo-4-chloro-3-fluoro-6-(cyclopropyloxy)benzonitrile; 6-(Cyclopropyloxy)-2-bromo-4-chloro-3-fluorobenzonitrile; Benzonitrile, 2-bromo-4-chloro-6-(cyclopropyloxy)-3-fluoro-; 2629317-94-6
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 2-Bromo-4-Chloro-6-(Cyclopropyloxy)-3-Fluoro- is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced R&D and scale-up activities. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.