Description

6β-Methylprednisolone Hemisuccinate is a hemisuccinate ester derivative of the potent glucocorticoid methylprednisolone, designed to enhance solubility and bioavailability for advanced pharmaceutical formulations. This high-purity intermediate is critical for the development of injectable and other parenteral drug products requiring precise and potent anti-inflammatory or immunosuppressive activity. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers focused on developing next-generation corticosteroid therapies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacturing of finished corticosteroid APIs.
• Injectable Formulation Development: Used in the research and production of soluble, ready-to-use injectable solutions for hospital and clinical use.
• Parenteral Drug Products: Essential for formulating drugs administered via intravenous (IV), intramuscular (IM), or subcutaneous routes.
• Anti-inflammatory & Immunosuppressive Therapies: Serves as a core component in medications for severe allergies, rheumatoid arthritis, lupus, and other autoimmune conditions.
• Research & Development: A valuable reference standard and building block in medicinal chemistry for novel glucocorticoid receptor modulators.
• Veterinary Pharmaceuticals: Employed in the development of high-potency anti-inflammatory treatments for animals.

Basic Information

Product Name	6β-Methylprednisolone Hemisuccinate
CAS No.	2376134-25-5
Molecular Formula	C₂₆H₃₄O₈
Molecular Weight	474.55 g/mol
Synonyms	6β-Methylprednisolone 21-Hemisuccinate; Methylprednisolone 21-Hemisuccinate; 6β-Methylprednisolone Hemisuccinate; U-67590A; 11β,17,21-Trihydroxy-6β-methylpregna-1,4-diene-3,20-dione 21-hemisuccinate; 6-Methyl-δ1-hydrocortisone 21-hemisuccinate; 6β-Methylprednisolone Succinate
EINECS	Contact for details

Quality Control

Our 6β-Methylprednisolone Hemisuccinate is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical development. Each batch is subjected to comprehensive analytical testing including HPLC for purity, identification by IR and NMR, and stringent control of related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.