Description

1-Piperidinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-4,4-Difluoro-, (αs)- is a sophisticated, high-purity chemical building block designed for advanced research and development. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical sector where precise molecular architecture is required. It is primarily utilized by medicinal chemists and process development scientists in the life sciences industry for creating novel therapeutic candidates, including peptide mimetics and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptidomimetic Research: Used in the design and construction of peptide analogs and mimetics for drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: A potential component in the linker or ligand structures of bifunctional molecules like PROTACs.
• Chemical Biology Probes: Employed in the creation of specialized probes for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of complex organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1-Piperidinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-4,4-Difluoro-, (αs)-
CAS No.	2255321-31-2
Molecular Formula	C25H28F2N2O4
Molecular Weight	458.50 g/mol
Synonyms	(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]methylamino]-4,4-difluoro-1-piperidinebutanoic acid; Fmoc-Difluoropiperidinebutanoic Acid derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4,4-difluoro-L-homopiperidinecarboxylic acid; 4,4-Difluoro-L-homopiperidine-2-carboxylic acid Fmoc derivative; Fmoc-N-Me-4,4-difluoro-homoPip-OH; CAS 2255321-31-2
EINECS	Contact for details

Quality Control

Our 1-Piperidinebutanoic Acid derivative is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.