Description

Benzonitrile, 3-(1,1-Difluoro-2-Hydroxyethyl)- is a high-value, fluorinated benzonitrile derivative characterized by its unique difluorohydroxyethyl side chain. This compound serves as a critical pharmaceutical intermediate and advanced building block in organic synthesis, enabling the introduction of fluorine atoms to modulate the biological activity and metabolic stability of target molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Building Block: Used in the development of next-generation herbicides and pesticides where the fluorine moiety enhances efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and structure-activity relationships.
• Polymer Modification: Can be incorporated into polymer backbones to impart specific properties like chemical resistance or altered solubility.
• Complex Molecule Synthesis: Utilized in multi-step syntheses to construct complex natural product analogs and other fine chemicals.

Basic Information

Product Name	Benzonitrile, 3-(1,1-Difluoro-2-Hydroxyethyl)-
CAS No.	2228993-53-9
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	3-(1,1-Difluoro-2-hydroxyethyl)benzonitrile; 3-(2-Hydroxy-1,1-difluoroethyl)benzonitrile; m-(1,1-Difluoro-2-hydroxyethyl)benzonitrile; 1-(3-Cyanophenyl)-2,2-difluoroethanol; 2,2-Difluoro-1-(3-cyanophenyl)ethanol; [3-(1,1-Difluoro-2-hydroxyethyl)phenyl] cyanide; Benzonitrile, m-(1,1-difluoro-2-hydroxyethyl)-
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3-(1,1-Difluoro-2-Hydroxyethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.