Description

5-Fluoro-3-Methoxy-2-Nitrobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring strategically placed fluoro, methoxy, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scale-up of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Serves as a core scaffold for developing new herbicides, fungicides, and insecticides, where the fluorine atom can enhance metabolic stability and bioavailability.
• Material Science: Used in the research and development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-withdrawing nitro and nitrile groups.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs), leveraging its ability to coordinate with various metal centers.
• Dye and Pigment Synthesis: Acts as an intermediate in the production of specialized dyes and pigments, where its substituents influence color and fastness properties.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D projects.

Basic Information

Product Name	5-Fluoro-3-Methoxy-2-Nitrobenzonitrile
CAS No.	2167455-03-8
Molecular Formula	C8H5FN2O3
Molecular Weight	196.14 g/mol
Synonyms	2-Nitro-5-fluoro-3-methoxybenzonitrile; 3-Methoxy-2-nitro-5-fluorobenzonitrile; 5-Fluoro-3-methoxy-2-nitrobenzonitrile; Benzonitrile, 5-fluoro-3-methoxy-2-nitro-; 2167455-03-8
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-3-Methoxy-2-Nitrobenzonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets rigorous in-house specifications, with purity typically exceeding 97% (HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.