Description

4-Bromo-5-Fluoro-2-Iodobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders and oncology.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides by introducing halogenated aromatic motifs into lead compounds.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Stille) due to the presence of bromine and iodine, allowing for sequential functionalization.
• Ligand Synthesis: Building block for the preparation of complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Used as a probe or tag in bioconjugation chemistry and for labeling biomolecules.

Basic Information

Product Name	4-Bromo-5-Fluoro-2-Iodobenzonitrile
CAS No.	2149601-45-4
Molecular Formula	C7H2BrFIN
Molecular Weight	325.90 g/mol
Synonyms	2-Iodo-4-bromo-5-fluorobenzonitrile; 4-Bromo-5-fluoro-2-iodobenzonitrile; 2-Cyano-4-bromo-5-fluoro-1-iodobenzene; Benzonitrile, 4-bromo-5-fluoro-2-iodo-; 1-Bromo-2-cyano-4-fluoro-5-iodobenzene; 5-Fluoro-4-bromo-2-iodobenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Fluoro-2-Iodobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming the product meets your specified requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.