Description

4-Bromo-2-Fluoro-5-Iodo-Benzonitrile is a high-value, multi-halogenated benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging the halogen atoms for bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for synthesizing advanced functional materials used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) due to the presence of bromo and iodo substituents, enabling rapid diversification of chemical space.
• Chemical Biology & Probe Development: Utilized in medicinal chemistry for creating molecular probes and labeled compounds for studying biological pathways and target engagement.
• Polymer & Material Science: Incorporated into specialty polymers and advanced materials to impart specific electronic or physical characteristics.

Basic Information

Product Name	4-Bromo-2-Fluoro-5-Iodo-Benzonitrile
CAS No.	2149598-28-5
Molecular Formula	C7H2BrFIN
Molecular Weight	325.91 g/mol
Synonyms	5-Bromo-2-fluoro-4-iodobenzonitrile; 2-Fluoro-4-bromo-5-iodobenzonitrile; 4-Bromo-2-fluoro-5-iodobenzonitrile; Benzonitrile, 4-bromo-2-fluoro-5-iodo-; 2149598-28-5; 4-Br-2-F-5-I-Bn
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-5-Iodo-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.