Description

4-Amino-5-Ethynyl-2-Fluorobenzonitrile is a high-value, multi-functional aromatic building block featuring a unique combination of reactive amino, ethynyl, and cyano groups on a fluorinated benzene core. This compound matters for its versatility in constructing complex molecular architectures, particularly in pharmaceutical and advanced materials research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as targeted drug discovery and the synthesis of novel polymers or liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, targeted cancer therapies, and other small-molecule active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging its fluorine atom for enhanced biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic electronic materials.
• Chemical Synthesis: Utilized in click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) and palladium-catalyzed cross-coupling reactions due to its reactive ethynyl group.
• Liquid Crystal & OLED Development: Acts as a core structure for creating new fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials.
• Bioconjugation & Probe Synthesis: Employed in the design of fluorescent probes, biomarkers, and bioconjugates for diagnostic and research applications.

Basic Information

Product Name	4-Amino-5-Ethynyl-2-Fluorobenzonitrile
CAS No.	2131007-03-7
Molecular Formula	C9H5FN2
Molecular Weight	160.15 g/mol
Synonyms	2-Fluoro-4-amino-5-ethynylbenzonitrile; 5-Ethynyl-2-fluoro-4-aminobenzonitrile; 4-Amino-5-ethynyl-2-fluorobenzene carbonitrile; Benzonitrile, 4-amino-5-ethynyl-2-fluoro-; 2131007-03-7; 4-Amino-5-ethynyl-2-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Ethynyl-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.