Description

3-(Fluoromethyl)Bicyclo[1.1.1]Pentan-1-Amine Hydrochloride is a high-value, synthetically challenging pharmaceutical intermediate characterized by its unique [1.1.1]propellane core. This compound matters for its role as a key building block in modern medicinal chemistry, enabling the exploration of novel three-dimensional chemical space for drug discovery. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents, particularly those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a bioisostere to replace traditional aromatic or aliphatic rings, improving metabolic stability, solubility, and potency of drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation therapeutics.
• Covalent Inhibitor Synthesis: The amine hydrochloride salt is utilized in creating covalent binding motifs for irreversible enzyme inhibitors.
• Peptidomimetics & Macrocycle Synthesis: Incorporated into constrained peptide analogs to enhance bioavailability and target selectivity.
• Chemical Biology Probes: Employed in the design of tool compounds for studying biological pathways and target validation.
• Agrochemical Research: Potential application in the discovery of new crop protection agents with novel modes of action.
• Material Science: Exploration of its use in creating novel polymers or frameworks with unique structural properties.

Basic Information

Product Name	3-(Fluoromethyl)Bicyclo[1.1.1]Pentan-1-Amine Hydrochloride
CAS No.	2108633-67-4
Molecular Formula	C7H13ClFN
Molecular Weight	165.64 g/mol
Synonyms	1-Amino-3-(fluoromethyl)bicyclo[1.1.1]pentane hydrochloride; 3-(Fluoromethyl)bicyclo[1.1.1]pentan-1-amine HCl; 3-(Fluoromethyl)-1-aminobicyclo[1.1.1]pentane hydrochloride; Bicyclo[1.1.1]pentan-1-amine, 3-(fluoromethyl)-, hydrochloride; [1.1.1]Propellane-3-methanol, 1-amino-, hydrochloride, 3-fluoro- derivative; FC-BCP-NH2·HCl; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 3-(Fluoromethyl)Bicyclo[1.1.1]Pentan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, MS) are provided. We support compliance with ICH Q7 guidelines and can tailor purity specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.