Description

3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-3-Deaza-Arabinouridine is a high-purity, fluorinated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is specifically engineered for its role as a key synthetic intermediate in the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers specializing in nucleoside chemistry and prodrug development. The precise modification of its sugar moiety makes it a critical component for probing biological mechanisms and developing targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of modified nucleoside analogs for antiviral and anticancer drug candidates.
• Antiviral Pro-drug Development: Used in research focused on creating novel treatments for viral infections by targeting viral polymerase enzymes.
• Oncology Research: Employed in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Tool: Acts as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related pathways.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based drugs.
• Fine Chemical Synthesis: A specialized reagent for constructing complex, fluorinated molecular architectures in custom synthesis projects.

Basic Information

Product Name	3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-3-Deaza-Arabinouridine
CAS No.	2095417-46-0
Molecular Formula	C24H19FN2O7
Molecular Weight	466.42 g/mol
Synonyms	2'-Deoxy-2'-fluoro-3-deaza-arabinouridine 3',5'-dibenzoate; 2'-Fluoro-2'-deoxy-3-deaza-arabinouridine 3',5'-dibenzoate; 3-Deaza-2'-deoxy-2'-fluorouridine 3',5'-dibenzoate; 3-Deaza-2'-fluoro-2'-deoxyarabinouridine 3',5'-dibenzoate; 1-[(2R,3R,4R,5R)-3,4-Bis(benzoyloxy)-5-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidine-2-one; 3-Deaza-2'-F-araU 3',5'-di-O-benzoate; Fluorinated 3-deaza nucleoside benzoate; 3'-O,5'-O-Dibenzoyl-2'-deoxy-2'-fluoro-3-deaza-arabinouridine
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-3-Deaza-Arabinouridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.