Description

2-Amino-6-Chloro-5-Fluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring strategically placed amino, chloro, and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where its halogenated aniline core provides bioactivity.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes, pigments, and optical brighteners due to its reactive amino and cyano groups.
• Cross-Coupling Reactions: An excellent substrate for Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions to create diverse biaryl and heteroaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in medicinal chemistry and process development.

Basic Information

Product Name	2-Amino-6-Chloro-5-Fluorobenzonitrile
CAS No.	2092610-02-9
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	6-Chloro-5-fluoro-2-aminobenzonitrile; 2-Amino-6-chloro-5-fluorobenzene carbonitrile; 5-Fluoro-6-chloro-2-aminobenzonitrile; Benzonitrile, 2-amino-6-chloro-5-fluoro-; 2-Amino-5-fluoro-6-chlorobenzonitrile; (6-Chloro-5-fluoropyridin-2-yl)methanamine (related isomer); ACFB; 2-AC-6-C-5-F-BN
EINECS	Contact for details

Quality Control

Our 2-Amino-6-Chloro-5-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.