Description

(S)-2,2,2-Trifluoro-1-(Oxetan-3-Yl)Ethan-1-Amine is a high-value, chiral amine building block featuring a trifluoromethyl group and an oxetane ring. This compound is critical for medicinal chemistry research, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing advanced drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially protease inhibitors and kinase inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to introduce fluorine and oxetane motifs, which can improve a compound's potency, lipophilicity, and pharmacokinetic profile.
• Agrochemical Research: Serves as a building block for novel pesticides and herbicides, where the trifluoromethyl group often confers enhanced biological activity.
• Ligand Synthesis: Utilized in the preparation of chiral ligands for asymmetric catalysis.
• Material Science: Potential monomer or cross-linker for specialty polymers with unique surface properties or chemical resistance.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-(Oxetan-3-Yl)Ethan-1-Amine
CAS No.	2089671-14-5
Molecular Formula	C6H8F3NO
Molecular Weight	167.13 g/mol
Synonyms	(S)-2,2,2-Trifluoro-1-(oxetan-3-yl)ethanamine; (S)-1-(Oxetan-3-yl)-2,2,2-trifluoroethanamine; (S)-3-(1-Amino-2,2,2-trifluoroethyl)oxetane; (S)-α-(Trifluoromethyl)oxetane-3-methanamine; (S)-Oxetan-3-yl(trifluoromethyl)methylamine; (S)-Amino(oxetan-3-yl)(trifluoromethyl)methane
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(Oxetan-3-Yl)Ethan-1-Amine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its chemical nature, keep away from strong bases and fluorinating agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.