Description

Mc-Val-Cit-Pab-Duocarmycin is a synthetic, highly potent duocarmycin derivative designed for advanced pharmaceutical research and development. This compound is a critical intermediate in the synthesis of antibody-drug conjugates (ADCs), enabling targeted cancer therapy with enhanced efficacy and reduced systemic toxicity. It is essential for researchers and developers in the fields of oncology, bioconjugation chemistry, and precision medicine who require high-purity, structurally defined payloads for next-generation therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in the construction of targeted ADCs for oncology.
• Oncology Research: Used as a key intermediate in the synthesis of novel duocarmycin-based chemotherapeutic agents.
• Bioconjugation Chemistry: Employed in studies focusing on linker-payload technology and site-specific conjugation strategies.
• Preclinical Drug Development: A vital component in the R&D pipeline for evaluating new targeted cancer therapies.
• Mechanistic Studies: Utilized in biochemical assays to study DNA alkylation and cell cycle arrest mechanisms.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for GMP-compliant manufacturing processes.

Basic Information

Product Name	Mc-Val-Cit-Pab-Duocarmycin
CAS No.	2055896-98-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MC-Val-Cit-PAB-Duocarmycin; Duocarmycin derivative MC-Val-Cit-PAB; MC-VC-PAB-Duocarmycin; (S)-2-((S)-2-(6-((2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexanamido)-3-methylbutanamido)-5-((S)-4-((1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl)oxy)-4-oxobutanamido)pentanoic acid; ADC Payload Duocarmycin; MC-Val-Cit-PAB-Duocarmycin SA; Valine-Citrulline-PAB-Duocarmycin linker-payload
EINECS	Contact for details

Quality Control

Our Mc-Val-Cit-Pab-Duocarmycin is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC and MS. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and regulatory compliance for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.