Description

4-Fluoro-2-Nitrophenyl Methanesulfonate is a high-purity, specialized organic intermediate featuring a reactive methanesulfonate (mesylate) ester group ortho to a nitro substituent on a fluorinated aromatic ring. This unique structure makes it a valuable building block for the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorine atom and nitro group impart specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The reactive mesylate group can participate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The presence of both fluorine and nitro groups activates the aromatic ring for selective nucleophilic substitution reactions.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	4-Fluoro-2-Nitrophenyl Methanesulfonate
CAS No.	2010955-38-9
Molecular Formula	C8H6FNO5S
Molecular Weight	247.20 g/mol
Synonyms	4-Fluoro-2-nitrophenyl mesylate; Methanesulfonic acid 4-fluoro-2-nitrophenyl ester; 2-Nitro-4-fluorophenyl methanesulfonate; (4-Fluoro-2-nitrophenyl) methanesulfonate; Mesyloxy-4-fluoro-2-nitrobenzene; 1-Fluoro-4-methanesulfonyloxy-3-nitrobenzene; 4-Fluoro-2-nitro-1-(methylsulfonyloxy)benzene
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitrophenyl Methanesulfonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.