Description

Ozarelix is a synthetic decapeptide and a potent, selective antagonist of the gonadotropin-releasing hormone (GnRH) receptor. This compound is a critical research tool and active pharmaceutical ingredient (API) for developing novel therapeutic agents targeting hormone-dependent conditions. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on oncology, endocrinology, and reproductive medicine.

Application

• Pharmaceutical Research & Development: As a key reference standard and active ingredient in preclinical studies for prostate cancer, breast cancer, and endometriosis.
• Clinical Trial Material (CTM): Serves as the API in the formulation of drug products for Phase I-III clinical investigations.
• Mechanistic Studies: Used in biochemical and pharmacological assays to study GnRH receptor signaling pathways and antagonism.
• Process Development: Employed in the development and optimization of synthetic routes and purification processes for peptide APIs.
• Analytical Method Development: Acts as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Ozarelix
CAS No.	295350-45-7
Molecular Formula	C₆₀H₈₀ClN₁₅O₁₂
Molecular Weight	1243.8 g/mol
Synonyms	SPI-153; Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph(L-hydroorotyl)-D4Aph(Chm)-Leu-Lys(iPr)-Pro-DAla-NH₂; [Ac-D-2-Nal1, D-4-Cpa2, D-3-Pal3, Ser4, 4-Aph(L-hydroorotyl)5, D-4-Aph(Chm)6, Leu7, Lys(iPr)8, Pro9, D-Ala10]GnRH; Ozarelix Acetate (common salt form)
EINECS	Contact for details

Quality Control

Our Ozarelix is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification by HPLC and MS, purity assay, and control of related substances and residual solvents, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.