Description

4-Iodophenylsulphur Pentafluoride (CAS NO 286947-68-0) is a high-value organosulfur fluoride building block, prized for its unique combination of a reactive pentafluorosulfur (SF5) group and an iodine substituent. This bifunctional nature makes it a critical intermediate for introducing both the highly lipophilic, metabolically stable SF5 moiety and a versatile iodine handle for further cross-coupling reactions into target molecules. It is essential for researchers and process chemists in the pharmaceutical and advanced materials sectors seeking to enhance the properties of novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of bioactive molecules, leveraging the SF5 group to improve metabolic stability, lipophilicity, and binding affinity.
• Agrochemical Research: Used in creating novel active ingredients where the SF5 group can contribute to increased pest selectivity and environmental persistence.
• Materials Science: Precursor for functionalized monomers and polymers, imparting unique electronic and surface properties due to the SF5 and aryl iodide functionalities.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and catalysts used in asymmetric synthesis and coupling reactions.
• Fluorine Chemistry & Library Synthesis: Enables efficient parallel and combinatorial synthesis for drug discovery programs via Suzuki, Sonogashira, and other palladium-catalyzed cross-couplings.
• Radiopharmaceutical Precursor: The iodine atom provides a potential site for radioiodination, useful in developing diagnostic imaging agents.

Basic Information

Product Name	4-Iodophenylsulphur Pentafluoride
CAS No.	286947-68-0
Molecular Formula	C6H4F5IS
Molecular Weight	306.06 g/mol
Synonyms	1-Iodo-4-(pentafluoro-λ6-sulfanyl)benzene; p-Iodophenylsulfur pentafluoride; 4-Iodophenylsulfur pentafluoride; (4-Iodophenyl)sulfur pentafluoride; SF5-Ph-I; 4-(Pentafluoro-λ6-sulfanyl)iodobenzene; 4-Iodo-1-(pentafluorosulfanyl)benzene; 4-SF5-C6H4-I
EINECS	Contact for details

Quality Control

Our 4-Iodophenylsulphur Pentafluoride is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.