Description

Benzenepropanenitrile, 2-Fluoro-B-Oxo-3-(Trifluoromethyl)- is a high-value fluorinated aromatic nitrile building block, distinguished by its unique trifluoromethyl and keto functional groups. This compound is critical for pharmaceutical and agrochemical research, enabling the synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing complex heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in kinase inhibitor and anti-inflammatory agent research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the trifluoromethyl group improves lipophilicity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, contributing unique electronic and optical properties.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions and nucleophilic addition reactions to introduce complex fluorinated motifs.
• Chemical Research & Development: Essential for academic and industrial labs exploring new reaction methodologies and fluorine chemistry.

Basic Information

Product Name	Benzenepropanenitrile, 2-Fluoro-B-Oxo-3-(Trifluoromethyl)-
CAS No.	267881-02-7
Molecular Formula	C10H5F4NO
Molecular Weight	231.15 g/mol
Synonyms	2-Fluoro-β-oxo-3-(trifluoromethyl)benzenepropanenitrile; 3-(Trifluoromethyl)-2-fluorobenzoylacetonitrile; 2-Fluoro-3-(trifluoromethyl)benzoylacetonitrile; 1-(2-Fluoro-3-(trifluoromethyl)phenyl)-2-cyanoethan-1-one; α-Cyano-2-fluoro-3-(trifluoromethyl)acetophenone; 2-Fluoro-3-trifluoromethylbenzoyl methyl cyanide; [2-Fluoro-3-(trifluoromethyl)benzoyl]acetonitrile
EINECS	Contact for details

Quality Control

Our production of Benzenepropanenitrile, 2-Fluoro-B-Oxo-3-(Trifluoromethyl)- adheres to stringent in-process controls and final batch release testing. We guarantee high chemical purity and lot-to-lot consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.