Description

2,3-Difluorobenzoylacetonitrile is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a difluorophenyl ring and an activated methylene group, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of fluorinated organic semiconductors and liquid crystals for electronic applications.
• Chemical Biology Probes: Utilized to build fluorinated analogs of natural products for mechanism-of-action studies and bioimaging.

Basic Information

Product Name	2,3-Difluorobenzoylacetonitrile
CAS No.	267880-87-5
Molecular Formula	C9H5F2NO
Molecular Weight	181.14 g/mol
Synonyms	2,3-Difluoro-ω-cyanacetophenone; 3-Oxo-3-(2,3-difluorophenyl)propanenitrile; 1-(2,3-Difluorophenyl)-3-oxopropanenitrile; 2,3-Difluorobenzoyl methyl cyanide; (2,3-Difluorobenzoyl)acetonitrile; Acetonitrile, (2,3-difluorobenzoyl)-; 2,3-DFBA
EINECS	Contact for details

Quality Control

Our 2,3-Difluorobenzoylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.