Description

3,5-Trifluromethylbenzoylacetonitrile is a high-value fluorinated organic intermediate featuring a versatile β-ketonitrile functional group. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing heterocyclic cores and active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethylated pyrazole or pyridine heterocycles.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that benefit from the metabolic stability imparted by the trifluoromethyl groups.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and asymmetric synthesis.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and inhibitors for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3,5-Trifluromethylbenzoylacetonitrile
CAS No.	267880-81-9
Molecular Formula	C10H5F3NO
Molecular Weight	212.15 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzoylacetonitrile; 1-(3,5-Bis(trifluoromethyl)phenyl)-3-oxobutanenitrile; 4,4,4-Trifluoro-1-[3,5-bis(trifluoromethyl)phenyl]butane-1,3-dione; 3-Oxo-3-[3,5-bis(trifluoromethyl)phenyl]propanenitrile; 3,5-Di(trifluoromethyl)benzoylacetonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Trifluromethylbenzoylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.