Description

3-Chloro-4-Fluorobenzoylacetonitrile is a versatile and high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a critical building block for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers for specialized coatings.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring fluorinated benzoyl derivatives.

Basic Information

Product Name	3-Chloro-4-Fluorobenzoylacetonitrile
CAS No.	267880-79-5
Molecular Formula	C9H5ClFNO
Molecular Weight	197.59 g/mol
Synonyms	3-Chloro-4-fluorobenzoylacetonitrile; 4-Fluoro-3-chlorobenzoylacetonitrile; 1-(3-Chloro-4-fluorophenyl)-3-oxobutanenitrile; 3-Oxo-3-(3-chloro-4-fluorophenyl)propanenitrile; 3-Chloro-4-fluoro-β-oxobenzeneacetonitrile; (3-Chloro-4-fluorobenzoyl)acetonitrile; 3-Chloro-4-fluorobenzoylmethyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzoylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.