Description

Ethyl 2-Trifluoroacetyl-3-(N,N-Dimethylamino)-2-propenoate is a high-value, multi-functional chemical intermediate characterized by its reactive α,β-unsaturated ester moiety and trifluoroacetyl group. This compound is essential for synthesizing complex heterocyclic systems and fine chemicals, offering a versatile scaffold for introducing fluorinated and amino-substituted functionalities. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides to enhance bioavailability and environmental stability.
• Heterocyclic Chemistry: Serves as a crucial precursor for constructing complex nitrogen and oxygen-containing heterocycles like pyridines, pyrimidines, and pyrroles.
• Material Science Research: Employed in the development of specialty polymers and organic electronic materials that require fluorinated components.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products and biochemical probes for mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise introduction of trifluoroacetyl and dimethylamino groups.

Basic Information

Product Name	Ethyl 2-Trifluoroacetyl-3-(N,N-Dimethylamino)-2-propenoate
CAS No.	267243-86-7
Molecular Formula	C9H12F3NO3
Molecular Weight	239.19 g/mol
Synonyms	Ethyl (E)-3-(dimethylamino)-2-(trifluoroacetyl)acrylate; 2-Propenoic acid, 3-(dimethylamino)-2-(trifluoroacetyl)-, ethyl ester; Ethyl 3-(dimethylamino)-2-(trifluoroacetyl)acrylate; (E)-Ethyl 3-(dimethylamino)-2-(trifluoroacetyl)acrylate; N,N-Dimethyl-3-ethoxycarbonyl-4,4,4-trifluoro-3-buten-2-imine; TFAA-DMAD Adduct; Ethyl 2-(trifluoroacetyl)-3-(dimethylamino)acrylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-Trifluoroacetyl-3-(N,N-Dimethylamino)-2-propenoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and scale-up. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Yellow to amber liquid or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.