Description

17-Methoxycarbonyl Loteprednol is a key pharmaceutical intermediate in the synthesis of loteprednol etabonate, a potent corticosteroid. This compound matters for its critical role in producing high-purity active pharmaceutical ingredients (APIs) used in ophthalmic anti-inflammatory treatments. Pharmaceutical manufacturers and advanced R&D facilities require this high-quality intermediate to ensure the efficacy and safety of final drug products. Its precise chemical structure is essential for consistent batch-to-batch performance in complex synthesis pathways.

Application

• Primary intermediate in the synthesis of Loteprednol Etabonate API.
• Critical raw material for manufacturing ophthalmic suspensions and ointments targeting inflammation and pain.
• Used in pharmaceutical research and development for novel topical corticosteroid formulations.
• Key component in the production of controlled-release ophthalmic drug delivery systems.
• Employed in analytical laboratories as a reference standard for quality control and method development.
• Utilized in process chemistry for scaling up and optimizing API manufacturing routes.

Basic Information

Product Name	17-Methoxycarbonyl Loteprednol
CAS No.	265651-89-6
Molecular Formula	C₂₄H₃₁ClO₇
Molecular Weight	466.96 g/mol
Synonyms	Loteprednol 17-Carboxylic Acid, 17-Methyl Ester; Chloromethyl 17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylate; 17-Methoxycarbonyl Loteprednol Ester; Precursor to Loteprednol Etabonate; (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 17-Methoxycarbonyl Loteprednol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.