Description

4-Methyl-2-(trifluoromethyl)benzonitrile is a versatile fluorinated aromatic nitrile building block. This high-purity intermediate is critical for the synthesis of advanced pharmaceutical compounds and agrochemicals, offering a unique trifluoromethyl-substituted aromatic core. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A valuable reagent in cross-coupling reactions, cyanation processes, and as a precursor for corresponding carboxylic acids, amides, and heterocycles.
• Research & Development: Essential compound for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	4-Methyl-2-(trifluoromethyl)benzonitrile
CAS No.	261952-05-0
Molecular Formula	C9H6F3N
Molecular Weight	185.15 g/mol
Synonyms	2-Cyano-5-methylbenzotrifluoride; 2-(Trifluoromethyl)-4-methylbenzonitrile; 4-Methyl-2-(trifluoromethyl)benzonitrile; α,α,α-Trifluoro-4-methyl-o-tolunitrile; 2-(Trifluoromethyl)-p-tolunitrile; 5-Methyl-2-(trifluoromethyl)benzonitrile; 2-Trifluoromethyl-4-methylbenzonitrile; 4-Methyl-α,α,α-trifluoro-o-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.