Description

2,5-Difluoro-4-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic nitrile building block. This compound matters for its unique trifluoromethyl and difluoro substitution pattern, which is critical for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Organic Electronics: Employed in the synthesis of electron-deficient units for organic semiconductors and OLED materials.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the development of specialty polymers with enhanced chemical resistance and thermal stability.
• Chemical Research & Development: A versatile building block for exploring new reactions in organofluorine chemistry and creating compound libraries for screening.

Basic Information

Product Name	2,5-Difluoro-4-(Trifluoromethyl)Benzonitrile
CAS No.	261945-24-8
Molecular Formula	C8H2F5N
Molecular Weight	207.10 g/mol
Synonyms	4-(Trifluoromethyl)-2,5-difluorobenzonitrile; 2,5-Difluoro-α,α,α-trifluoro-p-tolunitrile; 2,5-Difluoro-4-trifluoromethylbenzonitrile; 1,4-Difluoro-2-cyano-5-(trifluoromethyl)benzene; 2,5-Difluoro-4-(trifluoromethyl)benzonitrile; 261945-24-8; 4-Cyano-2,5-difluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent quality suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light as indicated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.