Description

2,4-Difluoro-5-(Trifluoromethyl)Benzonitrile is a high-value, multi-fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both difluoro and trifluoromethyl substituents on a benzonitrile core, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the development of novel materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Advanced Polymer Modifiers: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	2,4-Difluoro-5-(Trifluoromethyl)Benzonitrile
CAS No.	261945-18-0
Molecular Formula	C8H2F5N
Molecular Weight	207.10 g/mol
Synonyms	5-(Trifluoromethyl)-2,4-difluorobenzonitrile; 2,4-Difluoro-α,α,α-trifluoro-m-toluonitrile; 2,4-Difluoro-5-trifluoromethylbenzonitrile; 3-Cyano-4,6-difluorobenzotrifluoride; 4,6-Difluoro-3-(trifluoromethyl)benzonitrile; Benzene, 2,4-difluoro-5-(trifluoromethyl)cyano-; 261945-18-0 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-(Trifluoromethyl)Benzonitrile is produced and tested under a strict quality management system. We guarantee high purity and consistency to meet the exacting standards of advanced synthetic applications. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles, is provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.