Description

3-Chloro-4-(Trifluoromethoxy)Benzyl Bromide is a versatile and high-value halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethoxy substituents, makes it an essential precursor for introducing functionalized benzyl groups into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its reliable reactivity profile ensures consistent performance in key transformations such as nucleophilic substitutions and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed reactions.
• Material Science Research: Employed in the synthesis of functionalized monomers and polymers for advanced materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Benzyl Bromide
CAS No.	261763-18-2
Molecular Formula	C8H5BrClF3O
Molecular Weight	289.48 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-4-(trifluoromethoxy)benzene; (3-Chloro-4-(trifluoromethoxy)phenyl)methyl bromide; α-Bromo-3-chloro-4-(trifluoromethoxy)toluene; 3-Chloro-4-trifluoromethoxybenzyl bromide; 3-Chloro-α-bromo-4-(trifluoromethoxy)toluene; Benzene, 1-(bromomethyl)-3-chloro-4-(trifluoromethoxy)-; 4-Trifluoromethoxy-3-chlorobenzyl bromide
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-4-(Trifluoromethoxy)Benzyl Bromide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We are committed to meeting the exacting standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging. Store separately from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.