Description

3-Chloro-2-Fluoro-5-(Trifluoromethyl)Phenylacetonitrile is a high-value, multi-functional aromatic nitrile building block distinguished by its unique halogen and trifluoromethyl substitution pattern. This compound is critical for the synthesis of advanced agrochemicals and pharmaceuticals, where its structure imparts desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries for creating novel active ingredients and intermediates.

Application

• Agrochemical Intermediate: A key synthon for developing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl and halogen groups.
• Pharmaceutical Building Block: Used in the research and synthesis of active pharmaceutical ingredients (APIs), particularly in molecules targeting central nervous system (CNS) and inflammatory diseases.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in catalytic processes and material science.
• Functional Material Development: Employed in the research of organic electronic materials, such as OLEDs, due to its electron-withdrawing character.
• Custom Synthesis and Contract Manufacturing: An essential intermediate for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-(Trifluoromethyl)Phenylacetonitrile
CAS No.	261763-15-9
Molecular Formula	C9H4ClF4N
Molecular Weight	237.58 g/mol
Synonyms	2-(3-Chloro-2-fluoro-5-(trifluoromethyl)phenyl)acetonitrile; (3-Chloro-2-fluoro-5-(trifluoromethyl)phenyl)acetonitrile; 3-Chloro-2-fluoro-5-trifluoromethylphenylacetonitrile; 2-Fluoro-3-chloro-5-trifluoromethylphenylacetonitrile; Benzeneacetonitrile, 3-chloro-2-fluoro-5-(trifluoromethyl)-; CAS 261763-15-9
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate, ensuring batch-to-batch consistency and high purity suitable for demanding synthetic applications. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with comprehensive identity confirmation via FT-IR and NMR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with each shipment. Specifications can be tailored to meet specific project requirements, including higher purity grades for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.