Description

3-Chloro-2-Fluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzyl or chlorobenzyl motif.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated components for electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination for constructing biaryl systems.
• Functional Material Development: Intermediate for creating specialty polymers, dyes, and advanced organic frameworks with specific electronic characteristics.
• Chemical Research & Process Development: A valuable reagent for method development and scaling novel synthetic routes in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	3-Chloro-2-Fluorophenylacetonitrile
CAS No.	261762-98-5
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	(3-Chloro-2-fluorophenyl)acetonitrile; 2-Fluoro-3-chlorobenzyl cyanide; 2-Chloro-6-fluorobenzyl cyanide; 3-Chloro-2-fluorobenzeneacetonitrile; α-Cyano-3-chloro-2-fluorotoluene; 2-(3-Chloro-2-fluorophenyl)acetonitrile; 3-Chloro-2-fluoro-α-tolunitrile
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-Fluorophenylacetonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support customer audits to meet regulatory requirements for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and strong oxidizing agents. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.