Description

4-(4-Fluorobenzoyl)-3-(Hydroxymethyl)Benzonitrile is a high-purity fluorinated aromatic intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a versatile building block in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific fluorinated benzoyl and hydroxymethyl functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides where the fluorobenzoyl moiety enhances biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Polymer Modification Agent: Employed to introduce specific functional groups into polymer chains to alter physical properties like thermal stability or solubility.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorination reactions and heterocyclic chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Item	Details
Product Name	4-(4-Fluorobenzoyl)-3-(Hydroxymethyl)Benzonitrile
CAS No.	260371-16-2
Molecular Formula	C15H10FNO2
Molecular Weight	255.25 g/mol
Synonyms	3-(Hydroxymethyl)-4-(4-fluorobenzoyl)benzonitrile; 4'-Fluoro-3'-(hydroxymethyl)[1,1'-biphenyl]-4-carbonitrile; 4-(4-Fluorobenzoyl)-3-hydroxymethylbenzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 4'-fluoro-3'-(hydroxymethyl)-; 260371-16-2; 4-Fluoro-α-oxo[1,1'-biphenyl]-3-acetonitrile, 4'-hydroxymethyl- (related structure)
EINECS	Contact for details

Quality Control

Our 4-(4-Fluorobenzoyl)-3-(Hydroxymethyl)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.