Description

Ethyl 3,3,3-Trifluoro-2-Hydroxy-2-[4-(Methylamino)Phenyl]Propanoate is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key chiral intermediate, enabling the construction of complex molecules with precise stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis, crucial for efficient and selective chemical manufacturing.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique surface properties and durability.
• Chemical Biology Probes: Utilized to develop fluorinated analogs of biological molecules for metabolic pathway studies and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	Ethyl 3,3,3-Trifluoro-2-Hydroxy-2-[4-(Methylamino)Phenyl]Propanoate
CAS No.	254732-48-4
Molecular Formula	C12H14F3NO3
Molecular Weight	277.24 g/mol
Synonyms	Ethyl 2-Hydroxy-2-[4-(methylamino)phenyl]-3,3,3-trifluoropropanoate; 2-Hydroxy-2-(4-methylaminophenyl)-3,3,3-trifluoropropionic Acid Ethyl Ester; Ethyl α-Hydroxy-α-(4-methylaminophenyl)-β,β,β-trifluoropropionate; TFMEP Intermediate; 3,3,3-Trifluoro-2-hydroxy-2-(4-methylaminophenyl)propionic Acid Ethyl Ester; CAS 254732-48-4; ATF Building Block
EINECS	Contact for details

Quality Control

Our Ethyl 3,3,3-Trifluoro-2-Hydroxy-2-[4-(Methylamino)Phenyl]Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting R&D and pre-clinical standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.