Description

2-Fluoro-1-(Methylsulfonyl)-4-Nitrobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, leveraging the fluorine and sulfone groups for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced materials with specific electronic or optical properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it an excellent substrate for nucleophilic substitution reactions to introduce diverse functional groups.

Basic Information

Product Name	2-Fluoro-1-(Methylsulfonyl)-4-Nitrobenzene
CAS No.	252561-33-4
Molecular Formula	C7H6FNO4S
Molecular Weight	219.19 g/mol
Synonyms	1-Fluoro-2-(Methylsulfonyl)-5-Nitrobenzene; 2-Fluoro-1-Methylsulfonyl-4-Nitrobenzene; 4-Nitro-2-Fluorophenyl Methyl Sulfone; 2-Fluoro-4-Nitrophenyl Methyl Sulfone; 1-(Methylsulfonyl)-2-Fluoro-4-Nitrobenzene; 2-Fluoro-α,α,α-trifluoro-4-nitrobenzenemethanesulfonate (Related); Benzene, 2-fluoro-1-(methylsulfonyl)-4-nitro-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-1-(Methylsulfonyl)-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available for every shipment. We support cGMP standards for pharmaceutical applications and can provide material suitable for research and commercial-scale development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.