Description

2,4,6-Trifluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which profoundly influences the electronic and physical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl or related pharmacophores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in display technologies, leveraging the fluorine atoms to modify dielectric anisotropy and viscosity.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Cross-Coupling Reactions: The nitrile and halogenated aryl group make it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing diverse chemical libraries for screening.

Basic Information

Product Name	2,4,6-Trifluorophenylacetonitrile
CAS No.	243666-14-0
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	2-(2,4,6-Trifluorophenyl)acetonitrile; (2,4,6-Trifluorophenyl)acetonitrile; 2,4,6-Trifluorobenzeneacetonitrile; α-Cyano-2,4,6-trifluorotoluene; 2,4,6-Trifluorophenyl cyanomethyl; 243666-14-0; Acetonitrile, (2,4,6-trifluorophenyl)-
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended long-term storage temperature is 2-8°C. The container must be kept tightly sealed due to sensitivity to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.