Description

2,3,4-Trifluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which significantly influences the electronic and steric properties of target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and oncology drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethylphenyl moiety enhances bioactivity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a starting material for fluorinated liquid crystals used in high-performance displays.
• Functional Material Development: Employed in the synthesis of specialty polymers, dyes, and electronic chemicals requiring fluorinated aromatic units.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations to construct complex biaryl systems.
• Nitrile Transformation Chemistry: The cyano group can be readily converted to carboxylic acids, amides, amines, and tetrazoles, expanding its utility in medicinal chemistry.

Basic Information

Product Name	2,3,4-Trifluorophenylacetonitrile
CAS No.	243666-13-9
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	(2,3,4-Trifluorophenyl)acetonitrile; 2,3,4-Trifluorobenzeneacetonitrile; α-Cyano-2,3,4-trifluorotoluene; 2-(2,3,4-Trifluorophenyl)acetonitrile; 243666-13-9; 2,3,4-Trifluorophenyl cyanomethyl; Acetonitrile, (2,3,4-trifluorophenyl)-
EINECS	Contact for details

Quality Control

Our 2,3,4-Trifluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.