Description

4-[3,5-Di(Trifluoromethyl)Phenoxy]Benzonitrile is a high-value, fluorinated aromatic nitrile building block designed for advanced chemical synthesis. Its unique structure, featuring a benzonitrile core linked to a highly electron-deficient trifluoromethyl-substituted phenoxy group, makes it a critical intermediate for developing novel active ingredients. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical sectors seeking to incorporate fluorinated motifs to enhance metabolic stability, lipophilicity, and binding affinity. Its precise molecular architecture enables the creation of next-generation compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research, where the trifluoromethyl groups improve pharmacokinetic properties.
• Agrochemical Active Ingredient Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its fluorine content to increase efficacy and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a sophisticated monomer or intermediate in the production of high-performance electronic materials for displays and lighting.
• Advanced Polymer Modification: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Organic Synthesis & Catalysis Research: A valuable substrate in academic and industrial research for studying novel coupling reactions and catalytic processes involving fluorinated aromatics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke fluorinated compounds under cGMP or research-grade conditions.

Basic Information

Product Name	4-[3,5-Di(Trifluoromethyl)Phenoxy]Benzonitrile
CAS No.	243128-43-0
Molecular Formula	C15H6F6NO
Molecular Weight	330.21 g/mol
Synonyms	4-[3,5-Bis(trifluoromethyl)phenoxy]benzonitrile; Benzonitrile, 4-[3,5-bis(trifluoromethyl)phenoxy]-; 4-(3,5-Bis(trifluoromethyl)phenoxy)benzonitrile; 3,5-Bis(trifluoromethyl)phenyl 4-cyanophenyl ether; 4-Cyano-3',5'-bis(trifluoromethyl) diphenyl ether
EINECS	Contact for details

Quality Control

Every batch of 4-[3,5-Di(Trifluoromethyl)Phenoxy]Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR are available for each lot. Our quality commitment supports compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.