Description

5-Fluoro-2-(trifluoromethyl)benzonitrile is a high-value fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to influence dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Fluorinated Polymer Modifier: Acts as a monomer or cross-linking agent to introduce fluorine into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile building block for Suzuki, Sonogashira, and other cross-coupling reactions to create complex, multi-substituted aromatic systems for material science and drug discovery.

Basic Information

Product Name	5-Fluoro-2-(Trifluoromethyl)Benzonitrile
CAS No.	240800-45-7
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2-Cyano-4-fluorobenzotrifluoride; 4-Fluoro-2-(trifluoromethyl)benzonitrile; 5-Fluoro-α,α,α-trifluoro-o-tolunitrile; 2-(Trifluoromethyl)-5-fluorobenzonitrile; 5-Fluoro-2-trifluoromethylbenzonitrile; Benzonitrile, 5-fluoro-2-(trifluoromethyl)-; 240800-45-7
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.