Description

2,3-Difluoro-4-(trifluoromethyl)phenylacetonitrile is a high-value, multi-fluorinated aromatic nitrile building block. This compound is critical for introducing the 2,3-difluoro-4-(trifluoromethyl)phenyl moiety into advanced molecular architectures, significantly altering physicochemical properties like lipophilicity, metabolic stability, and binding affinity. It is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research where fluorination is strategically employed.
• Agrochemical Synthesis: Used in constructing advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Organic Electronics: Building block for electron-deficient units in organic semiconductors, n-type materials, and non-fullerene acceptors for photovoltaic applications.
• Advanced Material Research: Utilized in academic and industrial R&D for creating novel fluorinated polymers, ligands for catalysis, and specialty fine chemicals.

Basic Information

Product Name	2,3-Difluoro-4-(trifluoromethyl)phenylacetonitrile
CAS No.	240800-44-6
Molecular Formula	C9H4F5N
Molecular Weight	221.13 g/mol
Synonyms	2,3-Difluoro-4-(trifluoromethyl)benzyl cyanide; (2,3-Difluoro-4-(trifluoromethyl)phenyl)acetonitrile; α-Cyano-2,3-difluoro-4-(trifluoromethyl)toluene; 2-(2,3-Difluoro-4-(trifluoromethyl)phenyl)acetonitrile; 240800-44-6; 2,3-Difluoro-α-(trifluoromethyl)phenylacetonitrile (related isomer); 4-(Trifluoromethyl)-2,3-difluorophenylacetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-4-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure consistency and reliability for your critical synthesis steps. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.